We are delighted to share the publication of our most recent research paper. The article titled “The Role of Lipid Intrinsic Curvature in the Droplet Interface Bilayer” is now available in the Langmuir, the publication of American Chemical Society. The open access article can be seen in this link: https://pubs.acs.org/doi/10.1021/acs.langmuir.4c00270
In this paper, we investigate the effect of intrinsic curvature of lipid molecules assembled in a droplet interface bilayer array, on its free energy of formation. Using lipid molecules of different curvature values, the role of curvature stress on the values of free energy of formation is discussed, revealing a linear function of squared value of curvature. Our findings has significant potential to uncover the functional relationships between bilayer stress and protein function, and provide insights on the understanding of how proteins fold, bind, and act, in real cellular membranes.
We are so grateful for the harmonious efforts of all members of our research group and their contributions, as well as to the NSF for their funding support.
Professor Sunghee Lee
Department of Chemistry and Biochemistry
Iona University
715 North Avenue
New Rochelle, NY 10801
914-633-2638; SLee@iona.edu