Membrane Mimic

Lipid membranes represent the most important biological interface. The structure and properties of lipid membranes are strongly modulated by the composition of constituent lipids and the surrounding ionic aqueous medium. Our interests include how and to what extent do various compositions of lipids and salts affect the structure and property of lipid bilayers, using droplet interface bilayer as a model membrane. In our recent study, we demonstrated that the droplet interface bilayer (DIB) can be employed as a convenient model biological membrane to rapidly explore subtle structural effects on bilayer water permeability.

For more details, please visit our recent publications. (undergraduate co-authors are underlined)

Lee, Sunghee, Good to the Last Drop: Interfacial Droplet Chemistry, from Crystals to Biological Membranes, Acc. Chem. Res., 2018, 51 (10), 2524–2534. https://pubs.acs.org/doi/10.1021/acs.accounts.8b00277

Lopez, MariaDenver, JacquelineEvangelista, Sue EllenArmetta, AlessandraDi Domizio, Gabriella; Lee, Sunghee “Effects of Acyl Chain Unsaturation on Activation Energy of Water Permeability Across Droplet Bilayers of Homologous Monoglycerides: Role of Cholesterol” Langmuir2018, 34(5), 2147-2157.  http://dx.doi.org/10.1021/acs.langmuir.7b03590

Samuel BrazielKalen Sullivan, and Sunghee Lee. “Quantitative Raman microspectroscopy for water permeability parameters at a droplet interface bilayer.” Analyst2018, 143(3), 747-755. http://dx.doi.org/10.1039/c7an01349c

Maria LopezSue Ellen EvangelistaMelissa Morales, and Sunghee Lee, “Enthalpic Effects of Chain Length and Unsaturation on Water Permeability across Droplet Bilayers of Homologous Monoglycerides”, Langmuir2017, 33 (4), pp 900–912. http://dx.doi.org/10.1021/acs.langmuir.6b03932

P.J. MiliantaM. MuzzioJ. DenverG. Cawley, S.Lee, “Water Permeability Across Symmetric and Asymmetric Droplet Interface Bilayers: Interaction of Cholesterol Sulfate with DPhPC”, Langmuir, 31 (44), pp 12187–12196, 2015http://dx.doi.org/10.1021/acs.langmuir.5b02748

Z. MichalakM. MuzzioP.J. MiliantaR. Giacomini, S.Lee, “Effect of Monoglyceride Structure and Cholesterol Content on Water Permeability of the Droplet Bilayer”, Langmuir, 29 (51), 15919-15925, 2013http://pubs.acs.org/doi/abs/10.1021/la4040535

Z. MichalakD. FartashN. Haque, and S.Lee, “Tunable Crystallization via Osmosis-Driven Transport Across a Droplet Interface Bilayer”, CrystEngComm., 14, 7865-7868, 2012http://dx.doi.org/10.1039/C2CE26249E