Joseph Giancaspro (Biochemistry, Class of 2020) Presents Research on Capitol Hill

Sunghee Lee, Ph.D. • May 6, 2019

Joseph Giancaspro ’20 (Biochemistry) has just returned from Capitol Hill in Washington, DC, where he was selected to present his Chemistry research as part of the 23rd Annual Posters on the Hill event of the Council on Undergraduate Research. In his presentation and meetings with Congressional staff, he testified to the significance of undergraduate research initiatives to members of Congress. His research project, titled “The Ubiquitous Drug: Caffeine’s Effect on a Cell Membrane Model under Electrophysiological Observation,” went through a rigorous and highly competitive review process and was selected from among 350 applications from around the nation from the fields of Arts & Humanities, Social Sciences, Sciences, and Engineering. Joseph, along with his research mentor Dr. Sunghee Lee, Board of Trustees Endowed Professor of Chemistry, joined an elite group of undergraduate student researchers representing 43 states, on April 29-30, 2019 in Washington DC. They bore witness to the importance and the value of federal investment in undergraduate research, to members of Congress, congressional staff and federal government officials, including staff from Senator Schumer and Representative Sean Maloney. It is remarkable to note that Joseph is the second Iona student selected to showcase a research project at the Posters on the Hill event. This is a testament to the extraordinary quality of research activities undertaken by Iona undergraduate students.

Joseph has commented that being “selected to attend and present at the ‘Posters on the Hill’ event in Washington, DC was truly a once in a lifetime opportunity. . . . At the event, I had the opportunity to discuss my project with government representatives and lawmakers both at the event and in private sessions. It was very meaningful to have the chance to represent Iona College and be an advocate for institutions that support research at the undergraduate level. In addition, it was great to meet other undergraduate researchers from across the country to share personal experiences, successes and challenges”.

Such an experience undoubtedly teaches Iona’s undergraduate students that they can be a member of our nation’s scientific community, and can vocally advocate for the positive impact that undergraduate research has on our country’s education, intellectual leadership, and future success.

Exploring Graphene Oxide–Cholesterol Interactions Across Model Membranes

By Sunghee Lee • February 23, 2026
We’re pleased to announce our new collaborative publication, “Study of the Interaction Between Graphene Oxide and Cholesterol Using Different Artificial Membrane Models,” conducted in partnership with colleagues in Italy. This work investigates how graphene oxide—an emerging nanomaterial with biomedical promise—interacts with cholesterol within lipid membranes. By employing various artificial membrane systems, we examined how membrane composition and organization influence these interactions, revealing key insights into the physicochemical mechanisms at play. Our results contribute to a deeper understanding of how nanomaterials engage with biological membranes, providing valuable guidance for the safe and effective design of graphene-based biomedical applications. Congratulations to all team members and our Italian collaborators on this exciting achievement! The full article is available here: https://www.sciencedirect.com/science/article/pii/S0021979726002821 .

New Insights into Serotonin’s Relationship with Cell Membranes

By Sunghee Lee • February 23, 2026
In this study, we explored how the membrane environment shapes the behavior of serotonin, a key neurotransmitter involved in mood regulation and neural signaling. By systematically varying lipid composition in model membranes, we uncovered how differences in lipid charge, fluidity, and packing influence serotonin’s nonspecific interactions with bilayers. Our findings shed new light on the physical chemistry of neurotransmitter–membrane interactions, with potential implications for understanding serotonin’s diverse physiological functions and its role in receptor signaling. Congratulations to all co-authors for their outstanding work and collaboration! The article can be accessed here: https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00767

Recent Publication: How Tiny Molecules Shape the Flexibility of Cell Membranes

By Sunghee Lee • November 15, 2025
Our research team has uncovered new details about how small oil-like molecules influence the thickness and flexibility of cell membranes. These membranes, built from layers of lipids, contain tiny pockets of free space that help control how soft, dense, or permeable the membrane is. Our research team found that some smaller molecules can fit into these layers, making the membrane thicker, while larger or crystallizing ones get pushed out, leading to thinning. These changes help explain how different molecules inside a membrane affect its overall structure and function. This study not only expands our understanding of how biological membranes work but also points to new possibilities for creating custom-designed synthetic membranes for research and technology. Read more details here: https://pubs.acs.org/doi/10.1021/acs.jpcb.5c06296 Congratulations to the Project Symphpony team for their exciting findings and continued dedication to advancing membrane science!
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